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CBD pre-rolls are able to reduce pain and improve sleep by directly interacting with the receptors of the endocannabinoid system to include CB1 and CB2. CB1 and CB2 receptors are found throughout the central nervous system and attach with help from anandamide, a naturally occuring substance that was not discovered until 1992. The effectiveness that CBD has on the body is directly related to the areas of the brain that interact with the substance.

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